Hantavirus interferon regulation and virulence determinants
نویسندگان
چکیده
منابع مشابه
Hantavirus Regulation of Type I Interferon Responses
Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early interferon induction. PHV replication is blocked in human ECs, but not inhibited in IFN deficient VeroE6 cells and consistent with this, infecti...
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Hantaviruses cause two vascular permeability-based diseases and primarily infect endothelial cells which form the primary fluid barrier of the vasculature. Since hantavirus infections are not lytic, the mechanisms by which hantaviruses cause haemorrhagic fever with renal syndrome (HFRS) or Hantavirus Pulmonary Syndrome (HPS) are indeterminate. HPS is associated with acute pulmonary oedema and H...
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ژورنال
عنوان ژورنال: Virus Research
سال: 2014
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2013.12.041